Hydrochloric Acid → 4-Hydroxy-4-methylaminomethylpiperidine dihydrochloride

HRID 1681601ノート

反応式

HRID 1681601 の反応式
[OH:1][C:2]1([CH2:13][NH:14][CH3:15])[CH2:7][CH2:6][N:5](C(OCC)=O)[CH2:4][CH2:3]1.[ClH:16]>>[ClH:16].[ClH:16].[OH:1][C:2]1([CH2:13][NH:14][CH3:15])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 19382193HCID 19382193、化合物

生成物 1

HCID 193821784-Hydroxy-4-methylaminomethylpiperidine dihydrochloride

実験手順

3 g (13.9 mmol) of ethyl 4-hydroxy-4-methylaminomethylpiperidine-1-carboxylate are heated overnight under reflux with 30 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are stirred with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

後処理

  1. concentrationThe product is concentrated
  2. filtrationfiltered off with suction
  3. dry with materialdried in a vacuum desiccator over P4O10

出典と根拠

ORDレコード
ord-6714f538daa4493bbd8bf2761f34f1d6
出典データセット
uspto-grants-1992_12
特許番号
US05173484

反応ノート

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