Potassium Hydroxide → 99517-24-5

HRID 1681858ノート

反応式

HRID 1681858 の反応式
[C:1]([C:5]1[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=[C:7]([Cl:14])[CH:6]=1)([O:3]C)=[O:2].[OH-].[K+]>CO>[Cl:14][C:7]1[CH:6]=[C:5]([C:1]([OH:3])=[O:2])[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 14838646HCID 14838646、化合物

生成物 1

HCID 1483864799517-24-5収率 94.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 7-carbomethoxy-5-chlorobenzo[b]furan (6c) (3.02 g, 14.3 mmol) containing potassium hydroxide (3.22 g) in 100 ml of aqueous methanol (CH3OH/H2O=3/2) was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was acidified with conc. HCl to pH of about 1, cooled in freezer for several hours and filtered to give 7c as an off-white solid (2.65 g, 94.3%), mp 212°-215° C. NMR (DMSO-d6) δ8.0-6.87 (m, 5H, aromatic protons and OH).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. temperaturecooled in freezer for several hours
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-79da8bb4341746ca9fc90baff57ee9e6
出典データセット
uspto-grants-1992_12
特許番号
US05175173

反応ノート

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