Methanol → 1-Cyclopropylpiperazine

HRID 16819

反応式

HRID 16819 の反応式
Cl.Cl.[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1.CO>O>[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1

参加物

4

反応物 2

HCID 887MethanolHCID 212208121-Cyclopropylpiperazine dihydrochloride

生成物 1

HCID 47420041-Cyclopropylpiperazine収率 84.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-Cyclopropylpiperazine dihydrochloride (1.493 g, 7.5 mmol) was dissolved in water (5.00 mL) and methanol (5.00 mL) and converted to its freebase by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 3.5M ammonia in methanol and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.796 g, 84%) as an oil.

後処理

  1. washThe desired product was eluted from the column
  2. customwere evaporated to dryness

出典と根拠

ORDレコード
ord-52133c47f1534988bfc9e04dd961a467
出典データセット
uspto-grants-2010_06
特許番号
US07737149B2

関連ノート

読み込み中…