Methanol → 1-Cyclopropylpiperazine
反応式
Cl.Cl.[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1.CO>O>[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1参加物
4
実験手順
1-Cyclopropylpiperazine dihydrochloride (1.493 g, 7.5 mmol) was dissolved in water (5.00 mL) and methanol (5.00 mL) and converted to its freebase by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 3.5M ammonia in methanol and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.796 g, 84%) as an oil.
後処理
- washThe desired product was eluted from the column
- customwere evaporated to dryness
出典と根拠
- ORDレコード
- ord-52133c47f1534988bfc9e04dd961a467
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737149B2
反応ノート
読み込み中…