4,5-Dichlorophthalic anhydride → 2-Carbomethoxy 4,5-dichlorobenzoic acid

HRID 1681943ノート

反応式

HRID 1681943 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[O:8][C:6](=[O:7])[C:5]2=[CH:11][C:12]=1[Cl:13].[CH3:14][O-:15].[Na+]>CO>[C:6]([C:5]1[CH:11]=[C:12]([Cl:13])[C:2]([Cl:1])=[CH:3][C:4]=1[C:9]([OH:8])=[O:10])([O:15][CH3:14])=[O:7]

参加物

4

反応物 2

HCID 703344,5-Dichlorophthalic anhydrideHCID 10942334Sodium Methoxide

生成物 1

HCID 198042632-Carbomethoxy 4,5-dichlorobenzoic acid収率 92.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4,5-dichlorophthalic anhydride (1.0 g, 4.61 mmol) in 15 mL of methanol was added 0.25 g (9.22 mmol, 2.0 eq) of sodium methoxide. The suspension was stirred for 3 days and the methanol was removed in vacuo. The resultant white solid was suspended in 500 mL of CH2Cl2 and washed with 1N HCl. The organic phase was dried over anhydrous Na2SO4, filtered and the volatiles removed in vacuo to yield 1.06 g (92.5%) of the titled compound as a white powder.

後処理

  1. customthe methanol was removed in vacuo
  2. washwashed with 1N HCl
  3. dry with materialThe organic phase was dried over anhydrous Na2SO4
  4. filtrationfiltered
  5. customthe volatiles removed in vacuo

出典と根拠

ORDレコード
ord-f6fa263ca617444e8bd8f293493ce640
出典データセット
uspto-grants-1992_12
特許番号
US05175164

反応ノート

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