4-(1,1,4-Trimethylpentyl)phenylethyne → 4-(1,1,4-Trimethylpentyl)bromobenzene

HRID 1681952ノート

反応式

HRID 1681952 の反応式
[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][C:12](C#C)=[CH:11][CH:10]=1)([CH3:8])[CH2:3][CH2:4][CH:5]([CH3:7])[CH3:6].O=C(C1C=CC([Br:30])=CC=1)CCC(C)C.C[Al](C)C>CCCCCC>[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][C:12]([Br:30])=[CH:11][CH:10]=1)([CH3:8])[CH2:3][CH2:4][CH:5]([CH3:7])[CH3:6]

参加物

5

反応物 3

HCID 149896684-(1,1,4-Trimethylpentyl)phenylethyne2 回HCID 16682925TrimethylaluminumHCID 224090794-(1-Oxo-4-methyl-pentyl) bromobenzene2 回

生成物 1

HCID 224090834-(1,1,4-Trimethylpentyl)bromobenzene

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Reaction Scheme 6 discloses specific synthetic steps leading to 4-(1,1,4-trimethylpentyl)phenylethyne (Compound 32). In this synthetic route 4-(1-oxo-4-methyl-pentyl) bromobenzene (Compound 29, obtained as shown in Reaction Scheme 5) is reacted under a nitrogen atmosphere with trimethylaluminum in hexane to yield 4-(1,1,4-trimethylpentyl)bromobenzene (Compound 33). The bromobenzene derivative 33 is converted through the corresponding trimethylsilylethyne derivative 34 into the target intermediate 32 by treatment with trimethylsily ethyne and subsequently with KOH in isopropanol, as described above. ##STR10##

後処理

  1. customReaction Scheme 6

出典と根拠

ORDレコード
ord-26278ccf9b7645a282665d2a40e7d05f
出典データセット
uspto-grants-1992_12
特許番号
US05175185

反応ノート

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