6,7-Dimethyl-3,4-dihydroisoquinolin-1(2H)-one → 2-[(N-(2-(3,4-Dimethoxy-phenyl)-ethyl)-pyrrolidin-3-yl)-methyl]-6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline

HRID 1682064ノート

反応式

HRID 1682064 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[C:8](=[O:13])[NH:7][CH2:6][CH2:5]2.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH2:24][CH2:25][N:26]2[CH2:30][CH2:29][CH:28]([CH2:31]OS(C3C=CC=CC=3)(=O)=O)[CH2:27]2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH2:24][CH2:25][N:26]2[CH2:30][CH2:29][CH:28]([CH2:31][N:7]3[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][C:11]([CH3:12])=[C:2]([CH3:1])[CH:3]=4)[C:8]3=[O:13])[CH2:27]2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

参加物

3

反応物 2

HCID 178048946,7-Dimethyl-3,4-dihydroisoquinolin-1(2H)-oneHCID 54323491N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-benzenesulphonyloxymethyl-pyrrolidine

生成物 1

HCID 143067572-[(N-(2-(3,4-Dimethoxy-phenyl)-ethyl)-pyrrolidin-3-yl)-methyl]-6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline

実験手順

Prepared from 6,7-dimethyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline and N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-benzenesulphonyloxymethyl-pyrrolidine analogously to Example 2.

出典と根拠

ORDレコード
ord-238111618f0b4f01a9e5e593de464734
出典データセット
uspto-grants-1992_12
特許番号
US05175157

反応ノート

読み込み中…