HCID 21612897、化合物 → HCID 19804938、化合物

HRID 1682327ノート

反応式

HRID 1682327 の反応式
C([O:3][C:4](=[O:22])[CH:5]([NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])C>O>[CH2:15]([NH:14][CH:5](/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:11])([OH:12])=[O:10])[C:4]([OH:22])=[O:3])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

3

反応物 1

HCID 21612897HCID 21612897、化合物

生成物 1

HCID 19804938HCID 19804938、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1.00 g of E-2-benzylamino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester in 6 ml of water is stirred under reflux for 20 hours. The reaction mixture is concentrated to dryness by evaporation in vacuo. Ethanol is added to the residue, and the mixture is again concentrated by evaporation. This process is repeated twice more. The residue is dissolved in boiling methanol. After cooling there is obtained crystalline E-2-benzylamino-4-methyl-5-phosphono-3-pentenoic acid, m.p. 150° (decomp.).

後処理

  1. temperatureunder reflux for 20 hours
  2. concentrationThe reaction mixture is concentrated to dryness by evaporation in vacuo
  3. additionEthanol is added to the residue
  4. concentrationthe mixture is again concentrated by evaporation
  5. dissolutionThe residue is dissolved
  6. temperatureAfter cooling there

出典と根拠

ORDレコード
ord-5957bc2bcd3d4e96bac6fb48987e8bad
出典データセット
uspto-grants-1992_12
特許番号
US05175344

反応ノート

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