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Water → Pyridine-2-carbothioamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| 反応物 | 2-Pyridinecarboxamide | HCID 15070 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Pyridine-2-carbothioamide | HCID 1549499 | 74.8% |
反応手順
43 g of phosphorus pentasulfide were added slowly to 46.8 g of the amide of Stage A in 700 ml of tetrahydrofuran and the mixture was stirred for 4 hours at ambient temperature. The reaction mixture was poured into water and extracted with ether. The extracts were dried and the solvent was evaporated under reduced pressure. After chromatography on silica (eluant: CH2Cl2 --AcOEt 8-2), 10 g of expected product melting at 137° C. were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05635485 |
| 出典データセット | uspto-grants-1997_06 |
| ORD ID | ord-189d08015cd14c07b7bc2532edc628c1 |
| 出典メモ | uspto-grants-1997_06 |