Ethyl bromopyruvate → Ethyl 2-pyridin-2-yl-1,3-thiazole-4-carboxylate

HRID 1682426

反応式

HRID 1682426 の反応式
Br[CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[N:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16](=[S:18])[NH2:17]>C(O)C>[N:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[S:18][CH:2]=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:17]=1

参加物

4

反応物 2

HCID 66144Ethyl bromopyruvateHCID 1549499Pyridine-2-carbothioamide

生成物 1

HCID 10082761Ethyl 2-pyridin-2-yl-1,3-thiazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

16.3 ml of ethyl bromopyruvate were added dropwise to 15.9 g of the product of Stage B in 250 ml of ethanol and the mixture was refluxed for 5 hours. The solvent was evaporated under reduced pressure and the residue was chromatographed on silica (eluant: hexane--AcOEt 1-1) to obtain 10.2 g of the expected product melting at 69.1° C.

後処理

  1. temperaturethe mixture was refluxed for 5 hours
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was chromatographed on silica (eluant: hexane--AcOEt 1-1)

出典と根拠

ORDレコード
ord-6cfa5c1fff794f79ae9998c3d9b88abc
出典データセット
uspto-grants-1997_06
特許番号
US05635485

関連ノート

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