Lurosetron Mesylate → HCID 19044694、化合物
反応式
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[F:6][C:7]1[C:15]2[N:14]([CH3:16])[C:13]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[N:24]=[CH:25][NH:26][C:27]=4[CH3:28])[C:20](=[O:21])[C:12]=3[C:11]=2[CH:10]=[CH:9][CH:8]=1>O>[OH2:3].[OH2:21].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[F:6][C:7]1[C:15]2[N:14]([CH3:16])[C:13]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[N:24]=[CH:25][NH:26][C:27]=4[CH3:28])[C:20](=[O:21])[C:12]=3[C:11]=2[CH:10]=[CH:9][CH:8]=1参加物
3
反応条件
- 温度
- 45 °C
実験手順
To 6-fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one methanesulphonate (33.0 g) was added water (112 ml) and the mixture heated to 45° C. to give a clear yellow solution. This solution was allowed to reach ambient temperature, then cooled to 10° C., whereupon the mixture was filtered and the solid washed with water (20 ml, at 10° C.). The solid was dried at 48° C. in vacuo for 16 hours to give the title compound (20.3 g).