Potassium Carbonate → Dimethyl 4-(2-oxopropoxy)phenylmalonate

HRID 1682758

反応式

HRID 1682758 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.Br[CH2:18][C:19](=[O:21])[CH3:20].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:21]=[C:19]([CH3:20])[CH2:18][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 11715BromoacetoneHCID 3018973Dimethyl (4-hydroxyphenyl)malonate

生成物 1

HCID 21832135Dimethyl 4-(2-oxopropoxy)phenylmalonate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Following a procedure similar to that described in Preparation 3, but using 0.5 g of dimethyl 4-hydroxyphenylmalonate, 0.612 g of bromoacetone, 0.616 g of potassium carbonate and 90 ml of dimethylformamide, and then purifying the reaction product by column chromatography through silica gel, using a 2:3 by volume mixture of ethyl acetate and hexane as the eluent, the title compound was obtained having an Rf=0.37 (thin layer chromatography over silica gel, using a 2:3 by volume mixture of ethyl acetate and hexane as the developing solvent).

後処理

  1. customthat described in Preparation 3
  2. custompurifying the reaction product by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and hexane as the eluent

出典と根拠

ORDレコード
ord-1a2142f294fb48098cebf6132060bd15
出典データセット
uspto-grants-1997_06
特許番号
US05635534

関連ノート

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