Methanol → 2-[3-(3,4-Dichloro-phenyl)-1-(3,5-bis-(trifluoromethyl)-benzoyl)-pyrrolidin-3-yl]-ethanol

HRID 1682980

反応式

HRID 1682980 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[F:17][C:18]([F:33])([F:32])[C:19]1[CH:20]=[C:21]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[C:22](Cl)=[O:23].CO>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][N:11]([C:22](=[O:23])[C:21]3[CH:25]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:27]=[C:19]([C:18]([F:17])([F:32])[F:33])[CH:20]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

5

反応物 3

HCID 887Methanol2 回HCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 184644272-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanol

生成物 1

HCID 183333612-[3-(3,4-Dichloro-phenyl)-1-(3,5-bis-(trifluoromethyl)-benzoyl)-pyrrolidin-3-yl]-ethanol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

The method of example 3.1 was used with 2-[3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethanol (1 mmol) and 3,5-bis(trifluoromethyl)-benzoyl chloride (1 mmol) to obtain a residue. Chromatography of the residue on silica gel eluting sequentially with 1% methanol in dichloromethane and then 6% methanol in dichloromethane gave the title compound.

後処理

  1. customto obtain a residue

出典と根拠

ORDレコード
ord-dd659d48b57f463ba16bbe35cf609478
出典データセット
uspto-grants-1997_06
特許番号
US05635510

関連ノート

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