Hydrochloric Acid → 4-(Pyridin-2-yl)piperidine-4-carbonitrile hydrochloride

HRID 1683008ノート

反応式

HRID 1683008 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:20]#[N:21])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22].O1CCOCC1>>[ClH:22].[C:20]([C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)#[N:21]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 53439111Tert-butyl 4-cyano-4-(pyridin-2-YL)piperidine-1-carboxylate

生成物 1

HCID 673222724-(Pyridin-2-yl)piperidine-4-carbonitrile hydrochloride

実験手順

Prepare by the method of example 30.3 using 1-tert-butoxycarbonyl-4-cyano-4-(pyridin-2-yl)-piperidine (3 mmol) and HCl in dioxane (40 mmol, 4N). Concentrate the solvent in vacuo and dry under high vacuum to give the title compound.

後処理

  1. concentrationConcentrate the solvent in vacuo
  2. customdry under high vacuum

出典と根拠

ORDレコード
ord-ff7271a5c2654dbe9c2463f023de724e
出典データセット
uspto-grants-1997_06
特許番号
US05635510

反応ノート

読み込み中…