Hydrochloric Acid → 4-(Thiophen-2-yl)-piperidine-4-carboxylic acid amide hydrochloride

反応式

C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22].O1CCOCC1>>[ClH:22].[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[C:11]1([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 544168481-Tert-butoxycarbonyl-4-(thiophen-2-yl)-piperidine-4-carboxylic acid amide

生成物 1

HCID 675601084-(Thiophen-2-yl)-piperidine-4-carboxylic acid amide hydrochloride

実験手順

Prepare by the method of example 20.10 using 1-tert-butoxycarbonyl-4-(thiophen-2-yl)-piperidine-4-carboxylic acid amide (3 mmol) and HCl in dioxane (40 mmol, 4N) to give the title compound.

出典と根拠

ORDレコード: ord-fac21a07b0f94382909c8cad98794d19
出典データセット: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05635510

反応ノート

読み込み中…