Benzoyl chloride, 3,4,5-trimethoxy- → 4-(3,4-Dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-2-one

HRID 1683082ノート

反応式

HRID 1683082 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[CH2:13][NH:12][C:11](=[O:14])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([O:37][CH3:38])[C:34]=1[O:35][CH3:36])[C:29](Cl)=[O:30]>CN(C)C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[CH2:13][N:12]([C:29](=[O:30])[C:28]3[CH:27]=[C:26]([O:25][CH3:24])[C:34]([O:35][CH3:36])=[C:33]([O:37][CH3:38])[CH:32]=3)[C:11](=[O:14])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 211976714-(2-Tetrahydropyranyloxyethyl)-4-(3,4-dichlorophenyl)-2-pyrrolidone

生成物 1

HCID 537998014-(3,4-Dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-2-one

試薬・触媒・溶媒 1

HCID 949N,N-Dimethylaniline溶媒

反応条件

温度
90 °C

実験手順

Combine 4-(3,4-dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)ethyl]-pyrrolidin-2-one (as prepared in example 11.3) (5 mmol) and 3,4,5-trimethoxy-benzoyl chloride (5.0 mmol) in N,N-dimethylaniline (20 mL). Heat to 90° C. and stir for 24 h. Concentrate in vacuo . Partition the reaction mixture between dichloromethane and H2O. Separate the organic layer, dry over MgSO4, filter, and concentrate in vacuo to obtain a residue. Purify to give the title compound.

後処理

  1. concentrationConcentrate in vacuo
  2. customPartition the reaction mixture between dichloromethane and H2O
  3. customSeparate the organic layer
  4. dry with materialdry over MgSO4
  5. filtrationfilter
  6. concentrationconcentrate in vacuo
  7. customto obtain a residue
  8. customPurify

出典と根拠

ORDレコード
ord-146fde8b8e4c4bdeb6434dcb32d2c965
出典データセット
uspto-grants-1997_06
特許番号
US05635510

反応ノート

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