Carbon tetrabromide → 2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide

HRID 1683088

反応式

HRID 1683088 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:27][CH2:28]O)[CH2:13][N:12]([CH2:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].C(Br)(Br)(Br)[Br:31].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:27][CH2:28][Br:31])[CH2:10][CH2:11][N:12]([CH2:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[CH2:13]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 544091844-(3,4-Dichloro-phenyl)-4-2-hydroxy-ethyl-1-(3,4,5-trimethoxy-benzyl)-pyrrolidine

生成物 1

HCID 537092622-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide

実験手順

Prepare according to the method of example 57.7 using 4-(3,4-dichloro-phenyl)-4-2-hydroxy-ethyl-1-(3,4,5-trim ethoxy-benzyl)-pyrrolidine (5 mmol), carbon tetrabromide (6.3 mmol), and triphenylphosphine (7.5 mmol). Purify to obtain the title compound.

後処理

  1. customPrepare
  2. customPurify

出典と根拠

ORDレコード
ord-8b916f6c20a24aa18c97c618ac82e0b9
出典データセット
uspto-grants-1997_06
特許番号
US05635510

関連ノート

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