Formic Acid → HCID 86750935、化合物

反応式

C(N[C:4]1[C:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:8]=2[CH:7]=[CH:6][CH:5]=1)C.[CH:15]([OH:17])=O.[CH2:18]([N:20](CC)CC)[CH3:19]>>[CH:15]([NH:20][CH2:18][CH2:19][C:4]1[C:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:8]=2[CH:7]=[CH:6][CH:5]=1)=[O:17]

参加物

反応物 3

HCID 284Formic Acid

HCID 8471Triethylamine

HCID 19043049HCID 19043049、化合物

生成物 1

HCID 86750935HCID 86750935、化合物

実験手順

1-Ethylamino-benzocycloheptane (1 g, 5.3 mmol) was treated with formic acid (1.22 ml, 32 mmol) and triethylamine (1 ml, 7.2 mmol) and the mixture was heated under reflux for 22 hours under an argon atmosphere. After cooling to room temperature, the mixture was partitioned between diethyl ether (165 ml) and 5% aqueous NaHCO3 (100 ml). The organic layer was separated, dried (Na2SO4) and evaporated to a brown oil (1.06 g, 93%)

後処理

temperaturethe mixture was heated
temperatureunder reflux for 22 hours under an argon atmosphere
customthe mixture was partitioned between diethyl ether (165 ml) and 5% aqueous NaHCO3 (100 ml)
customThe organic layer was separated
dry with materialdried (Na2SO4)
customevaporated to a brown oil (1.06 g, 93%)

出典と根拠

ORDレコード: ord-3bbbe30c805a4a70b3f00e1bc127625b
出典データセット: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05637609

反応ノート

読み込み中…

参加物