Acetic Acid → 4,5,6,7-Tetrahydro-2-benzimidazolone
反応式
Br[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[NH2:9][C:10]([NH2:12])=[O:11].C([O-])(=O)C.[NH4+].C(O)(=O)C>O>[N:9]1[C:10](=[O:11])[N:12]=[C:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]=12参加物
6
実験手順
A mixture of 2-bromocyclohexanone (6.23 g, 0.035 mol) and urea (2.1 g, 0.035 mol) is refluxed in a solution of ammonium acetate (10 g), acetic acid (15 mL) and water (50 mL) for 4 h. Upon cooling slowly to room temp, white crystals form in the reaction vessel. The solid is collected by suction filtration, washed thoroughly with water and ether, and dried in vacuo to afford 4,5,6,7-tetrahydro-2-benzimidazolone (Compound 7).
後処理
- filtrationThe solid is collected by suction filtration
- washwashed thoroughly with water and ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-4314b798c9844be48a37a26ffe395954
- 出典データセット
- uspto-grants-1997_06
- 特許番号
- US05637725
反応ノート
読み込み中…