Bromine → 2-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide

HRID 1683725

反応式

HRID 1683725 の反応式
[Br:1][CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=[O:4].BrBr.[NH2:12][C:13]1[N:17]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:16]2[CH:26]=[CH:27][CH:28]=[CH:29][C:15]=2[N:14]=1>CC(C)=O>[Br-:1].[NH2:12][C:13]1[N:14]([CH2:2][C:3](=[O:4])[C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)[C:15]2[CH:29]=[CH:28][CH:27]=[CH:26][C:16]=2[N+:17]=1[CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

参加物

5

反応物 3

HCID 24408BromineHCID 5665591-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amineHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

生成物 1

HCID 1785085292-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

An ethereal solution of 2-bromoacetylthiophene (obtained by brominating 2-acetylthiophene (1.9 g, 15 mmol) with 0.8 ml (15 mmol) of bromine in 10 ml of dioxane and 15 ml of ether) is added to a hot solution of 2-amino-1-(2-piperidinoethyl)benzimidazole (2.44 g; 10 mmol) in 100 ml of acetone. Stir and maintain at room temperature. The next day, the title compound precipitate is collected by means of filtration and washed with acetone and with ether.

後処理

  1. filtrationThe next day, the title compound precipitate is collected by means of filtration
  2. washwashed with acetone and with ether

出典と根拠

ORDレコード
ord-32aaa76fc6324ca396b97f4b3f22d62d
出典データセット
uspto-grants-1997_06
特許番号
US05639756

関連ノート

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