2,4,6-Trimethoxybenzaldehyde → (E)-2-[(E)-2,4,6-trimethoxybenzylidene]-3-carboxy-4-phenyl-3-butenoic acid methyl ester

反応式

[CH3:1][O:2][C:3](=[O:17])[CH2:4]/[C:5](/[C:13]([O:15]C)=[O:14])=[CH:6]\[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:18][O:19][C:20]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[C:24]([O:30][CH3:31])[C:21]=1[CH:22]=O>>[CH3:1][O:2][C:3](=[O:17])/[C:4](=[CH:22]/[C:21]1[C:20]([O:19][CH3:18])=[CH:27][C:26]([O:28][CH3:29])=[CH:25][C:24]=1[O:30][CH3:31])/[C:5](/[C:13]([OH:15])=[O:14])=[CH:6]\[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:1][O:2][C:3](=[O:17])/[C:4](=[CH:22]\[C:21]1[C:20]([O:19][CH3:18])=[CH:27][C:26]([O:28][CH3:29])=[CH:25][C:24]=1[O:30][CH3:31])/[C:5](/[C:13]([OH:15])=[O:14])=[CH:6]\[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

反応物 2

HCID 700192,4,6-Trimethoxybenzaldehyde

HCID 6186590(E)-3-methoxycarbonyl-4-phenyl-3-butenoic acid methyl ester

生成物 2

HCID 86750969(E)-2-[(E)-2,4,6-trimethoxybenzylidene]-3-carboxy-4-phenyl-3-butenoic acid methyl ester

HCID 86750970(E)-2-[(Z)-2,4,6-trimethoxybenzylidene]-3-carboxy-4-phenyl-3-butenoic acid methyl ester

実験手順

(E)-3-Methoxycarbonyl-4-phenyl-3-butenoic acid methyl ester and 2,4,6-trimethoxybenzaldehyde are treated in the same manner as in Example 1-(1) to give (E)-2-[(E)-2,4,6-trimethoxybenzylidene]-3-carboxy-4-phenyl-3-butenoic acid methyl ester (foam) and (E)-2-[(Z)-2,4,6-trimethoxybenzylidene]-3-carboxy-4-phenyl-3-butenoic acid methyl ester (m.p. 208°-210° C.).