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4-Bromobenzyl bromide → HCID 19041639、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromobenzyl bromide | HCID 68527 | — |
| 反応物 | methyl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate | HCID 82067 | — |
| 反応物 | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Hexamethylphosphoramide | HCID 12679 | — |
| 生成物 | HCID 19041639 | HCID 19041639 | — |
反応手順
To the ethyl ester from Example 7, Step 1 (2.00 g, 8.10 mmol) dissolved in THF (40.0 mL) was added at -78° C. a 0.5M solution of KHMDS (16.0 mL, 8.10 mmol) in toluene and HMPA (200 μL). After a period of 10 min, 4-bromobenzyl bromide was added to the resulting mixture. The reaction mixture was brought to room temperature, quenched by the addition of 25% aqueous NH4OAc solution, extracted with EtOAc, dried over Na2SO4 and evaporated in vacuo. The title product was purified by flash chromotography (15% to 20% EtOAc in hexane) (1.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05639780 |
| 出典データセット | uspto-grants-1997_06 |
| ORD ID | ord-c7b0d7a0906f4359a7b3da0bd41fcd43 |
| 出典メモ | uspto-grants-1997_06 |