Ethanol → Acetic acid 2-amino-thiazol-4-ylmethyl ester

HRID 1685052ノート

反応式

HRID 1685052 の反応式
Cl[CH2:2][C:3](=O)[CH2:4][OH:5].[NH2:7][C:8]([NH2:10])=[S:9].[CH3:11][CH2:12][OH:13]>>[NH2:7][C:8]1[S:9][CH:2]=[C:3]([CH2:4][O:5][C:12](=[O:13])[CH3:11])[N:10]=1

参加物

4

反応物 3

HCID 702EthanolHCID 904941-Chloro-3-hydroxy-2-propanoneHCID 2723790Thiourea

生成物 1

HCID 21915033Acetic acid 2-amino-thiazol-4-ylmethyl ester

実験手順

1-Chloro-3-hydroxy-propan-2-one (15.06 g) and thiourea (8.36 g) were dissolved in EtOH (55 mL) and heated at reflux over 30 min. The reaction mixture was concentrated under reduced pressure to afford the desired product.

後処理

  1. temperatureheated
  2. temperatureat reflux over 30 min
  3. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-fa3d1f2b4e6948d5999f82786c304316
出典データセット
uspto-grants-2012_04
特許番号
US08148380B2

反応ノート

読み込み中…