Potassium Carbonate → HCID 67265901、化合物

HRID 1685379ノート

反応式

HRID 1685379 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([CH3:16])[NH:13][C:12](=[O:14])[NH:11][C:10]2=[O:15])[CH:5]=[C:6]([F:8])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:23][O:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29]Cl)=[CH:27][CH:26]=1>CN(C=O)C>[F:8][C:6]1[CH:5]=[C:4]([C:9]2([CH3:16])[NH:13][C:12](=[O:14])[N:11]([CH2:29][C:28]3[CH:31]=[CH:32][C:25]([O:24][CH3:23])=[CH:26][CH:27]=3)[C:10]2=[O:15])[CH:3]=[C:2]([F:1])[CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 699934-Methyloxybenzyl chlorideHCID 593704615-(3,5-Difluorophenyl)-5-methylimidazolidine-2,4-dione

生成物 1

HCID 67265901HCID 67265901、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

To a stirred solution of (±)-5-(3,5-difluorophenyl)-5-methylimidazolidine-2,4-dione from Step A (6.53 g, 28.9 mmol) in DMF (60 mL) was added potassium carbonate (4.39 g, 31.8 mmol) and 4-methoxybenzyl chloride (3.92 mL, 28.9 mmol). The reaction was stirred at ambient temperature for 16 h and at 50° C. for 1 h and then quenched with H2O (100 mL). The resulting precipitate was filtered and rinsed with water to provide the title compound. MS: m/z=347 (M+1).

後処理

  1. customquenched with H2O (100 mL)
  2. filtrationThe resulting precipitate was filtered
  3. washrinsed with water

出典と根拠

ORDレコード
ord-8774b5bde2f34db38183896fa703e367
出典データセット
uspto-grants-2012_04
特許番号
US08148390B2

反応ノート

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