化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Ether → tert-Butyl-(3-chloromethylsulfanyl-phenoxy)-dimethyl-silane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Bromochloromethane | HCID 6333 | — |
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | Potassium bisulfate | HCID 516920 | — |
| 反応物 | 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]benzenethiol | HCID 21976868 | — |
| 生成物 | tert-Butyl-(3-chloromethylsulfanyl-phenoxy)-dimethyl-silane | HCID 58734012 | — |
反応手順
DBU (914 mg, 6.0 mmol) was added to a solution of 3-(tert-Butyl-dimethyl-silanyloxy)-benzenethiol (1.00 g, 4.16 mmol) in bromo-chloro methane (5 ml) at room temperature. Stirring was continued for 2 hours and Et2O (50 ml) and 2M KHSO4 (30 ml) were added. The organic layer was separated, washed with 2M KHSO4 (30 ml) and brine (30 ml), dried (Na2SO4) and concentrated under reduced pressure. The resulting oil was analysed by 1H-NMR spectroscopy and was used without further purification. Yield: 1.01 g (84%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08148415B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-1507da1f180a4e8ea82054e9c26f141d |
| 出典メモ | uspto-grants-2012_04 |