Dihydro-2H-thiopyran-3(4H)-one → tert-Butyl 2-[4-(3-oxothian-2-ylidenemethyl)phenyl]propionate

反応式

[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:17])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[CH:5][CH:4]=1)=O.[O:18]=[C:19]1[CH2:24][CH2:23][CH2:22][S:21][CH2:20]1>>[O:18]=[C:19]1[CH2:24][CH2:23][CH2:22][S:21][C:20]1=[CH:1][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:17])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[CH:5][CH:4]=1

参加物

反応物 2

HCID 140474Dihydro-2H-thiopyran-3(4H)-one

HCID 86639388Tert-butyl 2-(4-formylphenyl)propionate

生成物 1

HCID 86639389tert-Butyl 2-[4-(3-oxothian-2-ylidenemethyl)phenyl]propionate収率 30%

実験手順

By using tert-butyl 2-(4-formylphenyl)propionate (500 mg) and 3-oxothiane (500 mg), the title compound (210 mg, 30%) was obtained in the same manner as that of Example 1.

出典と根拠

ORDレコード: ord-7eed7bd441db403c81cc20d9a2b1dd00
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08148421B2

反応ノート

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