Acetone → Methyl(4-chloro-3-methoxyphenyl)acetate
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]C(O)=O)=[CH:4][C:3]=1[OH:12].S([O:18][CH3:19])(OC)(=O)=O.[C:20](=[O:23])([O-])[O-].[K+].[K+].[CH3:26]C(C)=O>O>[CH3:20][O:23][C:19](=[O:18])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([O:12][CH3:26])[CH:4]=1参加物
6
実験手順
The product of example 1 step (iii) (1 g), dimethyl sulfate (1 ml), potassium carbonate (1.48 g) and acetone (20 ml) were charged to a flask and heated at reflux for 16 h. The reaction was diluted with water, extracted with EtOAc, dried (MgSO4) and evaporated under reduced pressure to give the subtitle compound (1.5 g).
後処理
- temperatureheated
- temperatureat reflux for 16 h
- extractionextracted with EtOAc
- dry with materialdried (MgSO4)
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-79a0e8db07cf4083a40355f7741959dd
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08148572B2
反応ノート
読み込み中…