1,2-Difluoro-4-ethylsulfonylbenzene → [3-[4-(Ethylsulfonyl)-2-fluorophenoxy]-5-(trifluoromethyl)phenyl]acetic acid

反応式

[OH:1][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:16]([S:18]([C:21]1[CH:26]=[CH:25][C:24](F)=[C:23]([F:28])[CH:22]=1)(=[O:20])=[O:19])[CH3:17]>>[CH2:16]([S:18]([C:21]1[CH:26]=[CH:25][C:24]([O:1][C:2]2[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=2)=[C:23]([F:28])[CH:22]=1)(=[O:19])=[O:20])[CH3:17]

参加物

反応物 2

HCID 265973661,2-Difluoro-4-ethylsulfonylbenzene

HCID 690656243-Hydroxy-5-(trifluoromethyl)phenylacetic acid

生成物 1

HCID 57791938[3-[4-(Ethylsulfonyl)-2-fluorophenoxy]-5-(trifluoromethyl)phenyl]acetic acid

実験手順

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 25 step (iv) and the product from example 10 step (ii).

出典と根拠

ORDレコード: ord-518625887359462c8d3fd7a1ae399b9f
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08148572B2

反応ノート

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