7-Amino-1-methyl-1,3,4,5-tetrahydro-benzo[B]azepin-2-one → HCID 57853796、化合物
反応式
[CH3:1][O:2][C:3]1[C:13]2[CH2:12][CH2:11][CH2:10][C:9](=[O:14])[NH:8][C:7]=2[C:6]([N+:15]([O-])=O)=[CH:5][CH:4]=1.NC1C=CC2N(C)C(=O)CCCC=2C=1>>[NH2:15][C:6]1[C:7]2[NH:8][C:9](=[O:14])[CH2:10][CH2:11][CH2:12][C:13]=2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=1参加物
3
実験手順
9-Amino-6-methoxy-1,3,4,5-tetrahydro-benzo[b]azepin-2-one was prepared from 6-methoxy-9-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one via reduction of the nitro group as described for the preparation of 7-Amino-1-methyl-1,3,4,5-tetrahydrobenzo[b]azepin-2-one. The crude product was purified by flash chromatography (EtOAc) and the product was obtained as a solid (36%); (400 MHz, DMSO-d6) δ6.62 (d, J=8.84 Hz, 1H), 6.56 (d, J 8.84 Hz, 1H), 4.52 (br s, 1H), 3.66 (s, 3H), 3.16 (d, J=3.31 Hz, 2H), 2.64 (m, 2H), 2.04 (m, 2H), 1.97 (m, 2H); MS (m/e) 207 (M+H).
後処理
- customThe crude product was purified by flash chromatography (EtOAc)