Ammonium Hydroxide → 4-Methyloxazole-5-carboxamide

HRID 1688334

反応式

HRID 1688334 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7]([O:9]CC)=O.[OH-].[NH4+:13]>>[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7]([NH2:13])=[O:9]

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 88558Ethyl 4-methyloxazole-5-carboxylate

生成物 1

HCID 785814-Methyloxazole-5-carboxamide

実験手順

A mixture of ethyl 4-methyloxazole-5-carboxylate (7.8 g, 50 mmoles) and ammonium hydroxide in a seal tube was stirred at rt for 12 hours. After completion of the reaction, solid was filtered and washed with water. The aqueous was extracted with ethyl acetate. The organic extract was dried and concentrated and combined with the filtered solid. Yield: 4.1 g (47%) 1H NMR (400 MHz, CDCl3): δ 2.38 (s, 3H), 7.92 (s, 1H). LCMS: (ES+) m/z=126.7 (M)+

後処理

  1. customAfter completion of the reaction, solid
  2. filtrationwas filtered
  3. washwashed with water
  4. extractionThe aqueous was extracted with ethyl acetate
  5. extractionThe organic extract
  6. customwas dried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-fe3d402ed9894436ac01d53ae19a3e8f
出典データセット
uspto-grants-2012_04
特許番号
US08148382B2

関連ノート

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