Pyridine → 3-chloro-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]propanamide

関与物質

反応手順

Synthesized according to general procedure 1: N′-(2-thiazolyl)sulfanilamide (8.37 g, 32.8 mmol), pyridine (5.3 mL, 65.6 mmol), 2-chloro-propionylchloride (3.8 mL, 39.4 mmol, 1.2 equiv) in DCM (400 mL). Yield: 2.70 g (24%) of a white solid. 1H-NMR (DMSO-d6) δ 10.41 (s, 1H), 7.77-7.72 (m, 4H), 7.25 (d, J=4.6 Hz, 1H), 6.82 (d, J=4.6 Hz, 1H), 3.88 (t, J=6.2 Hz, 2H), 2.86 (t, J=6.2 Hz, 2H). LC/MS (10-99%) M/Z: M+1 obs=346.1; tR=1.94 min.

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