1,3-dimethyl-1H-indole-2-carbaldehyde → 1-Ethyl-5-fluoro-3-(methylaminomethyl)-1H-indole
反応式
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[CH2:14]([N:16]1[C:24]2[C:19](=[CH:20][C:21]([F:25])=[CH:22][CH:23]=2)[C:18]([CH:26]=O)=[CH:17]1)[CH3:15].CN1C2C(=CC=CC=2)C(C)=C1C=O>>[CH2:14]([N:16]1[C:24]2[C:19](=[CH:20][C:21]([F:25])=[CH:22][CH:23]=2)[C:18]([CH2:26][NH:6][CH3:5])=[CH:17]1)[CH3:15]参加物
4
実験手順
According to the procedure of Preparation 11 (c), except substituting 1-ethyl-5-fluoro-1H-indole-3-carboxaldehyde (0.2 g, 1.9 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.1 g, 50%) was prepared as a viscous oil: MS (ES) m/e 207 (M+H)+.
出典と根拠
- ORDレコード
- ord-3a82d6836eb449eda5c2abdd257a1b1c
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08153652B2
反応ノート
読み込み中…