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Triethylamine → 1-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Cyclohexyl isocyanate | HCID 18502 | — |
| 反応物 | [5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine | HCID 66905404 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 1-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea | HCID 45111328 | — |
反応手順
In analogy to the procedure described in example 1.2, [5-chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in 1,2-dichloroethane in the presence of Et3N (3 eq.) for 4 days under reflux conditions to give the title compound as colorless foam. MS: m/e=523.3 [M+H+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08153663B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-527921a53d2e412c9dffc5861238d93c |
| 出典メモ | uspto-grants-2012_04 |