Cyclobutylamine → [2-(4-Chloro-phenyl)-2H-indazol-3-yl]-cyclobutyl-amine
反応式
[CH2:1]([N:5]([C:15]1[N:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[N:17]=[C:18]2[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]2)C(NC1CCCCC1)=O)[CH2:2][CH2:3][CH3:4].C1(N)CCC1>CN1CCCC1=O>[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([N:16]2[C:15]([NH:5][CH:1]3[CH2:2][CH2:3][CH2:4]3)=[C:23]3[C:18]([CH:19]=[CH:20][CH:21]=[CH:22]3)=[N:17]2)=[CH:29][CH:28]=1参加物
4
実験手順
In analogy to the procedure described in example 4.1, 3-chloro-2-(4-chloro-phenyl)-2H-indazole (Ardakani, Manouchehr; Smalley, Robert K.; Smith, Richard H., Synthesis (1979), (4), 308-9) was reacted with cyclobutylamine ([2516-34-9]) in N-methyl 2-pyrrolidone for 3 days at 175° C. in a sealed tube to give the title compound as yellow solid. MS: m/e=298.4 [M+H+].