Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]acrylate → Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]propanoate

HRID 1690608ノート

反応式

HRID 1690608 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][CH3:20]>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][CH3:20]

参加物

3

反応物 1

HCID 66907011Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]acrylate

生成物 1

HCID 66907182Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]propanoate収率 76.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]acrylate (16 g, 57 mmol) was dissolved in ethanol (190 mL) in a Parr apparatus. Nitrogen was bubbled for 15 minutes and Pd/C 10% (0.8 g) was added. The reaction mixture was submitted to hydrogenation under H2 atmosphere (3 bars) until the end of H2 consumption. The palladium was then filtered and the solvent was evaporated under reduced pressure to yield 12.3 g (76%) of the desired product as a colorless oil.

後処理

  1. customNitrogen was bubbled for 15 minutes
  2. additionPd/C 10% (0.8 g) was added
  3. customuntil the end of H2 consumption
  4. filtrationThe palladium was then filtered
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-daceb19e62f74f98af860b07cf6a5017
出典データセット
uspto-grants-2012_04
特許番号
US08153647B2

反応ノート

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