2-(3,5-Dimethyl-4-propoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 9-(3,5-Dimethyl-4-propoxy-phenyl)-10-fluoro-5,11-dihydro-6H-benzo[a]carbazole-3-carboxylic acid methyl ester

HRID 1690676ノート

反応式

HRID 1690676 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:23]=[CH:22][C:8]2[C:9]3[NH:10][C:11]4[C:16]([C:17]=3[CH2:18][CH2:19][C:7]=2[CH:6]=1)=[CH:15][CH:14]=[C:13](Cl)[C:12]=4[F:21])=[O:4].[CH3:24][C:25]1[CH:26]=[C:27](B2OC(C)(C)C(C)(C)O2)[CH:28]=[C:29]([CH3:35])[C:30]=1[O:31][CH2:32][CH2:33][CH3:34]>>[CH3:1][O:2][C:3]([C:5]1[CH:23]=[CH:22][C:8]2[C:9]3[NH:10][C:11]4[C:16]([C:17]=3[CH2:18][CH2:19][C:7]=2[CH:6]=1)=[CH:15][CH:14]=[C:13]([C:27]1[CH:28]=[C:29]([CH3:35])[C:30]([O:31][CH2:32][CH2:33][CH3:34])=[C:25]([CH3:24])[CH:26]=1)[C:12]=4[F:21])=[O:4]

参加物

3

反応物 2

HCID 576184902-(3,5-Dimethyl-4-propoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 669046639-Chloro-10-fluoro-5,11-dihydro-6H-benzo[a]carbazole-3-carboxylic acid methyl ester

生成物 1

HCID 160483419-(3,5-Dimethyl-4-propoxy-phenyl)-10-fluoro-5,11-dihydro-6H-benzo[a]carbazole-3-carboxylic acid methyl ester

実験手順

A sample of crude 9-Chloro-10-fluoro-5,11-dihydro-6H-benzo[a]carbazole-3-carboxylic acid methyl ester (prepared as in example 57, step 2) and 2-(3,5-Dimethyl-4-propoxy-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane are coupled as in example 19, step 2 to afford the title material: ESMS m/z/z 458 (M+H+).

出典と根拠

ORDレコード
ord-2f028fe06a5b405788387a72a416f1d8
出典データセット
uspto-grants-2012_04
特許番号
US08153671B2

反応ノート

読み込み中…