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HRID 1690727作成日：2026年10月27日
4-(5-Hydroxymethyl-imidazol-1-yl)-3,3-dimethyl-isochroman-1-one → 3-(3,3-dimethyl-1-oxo-isochroman-4-yl)-3H-imidazole-4-carbaldehyde
https://huagongshe.com/reaction/1690727
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-(5-Hydroxymethyl-imidazol-1-yl)-3,3-dimethyl-isochroman-1-one | HCID 57781122 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3-(3,3-dimethyl-1-oxo-isochroman-4-yl)-3H-imidazole-4-carbaldehyde | HCID 24802690 | — |
反応手順
To a solution of 4-(5-hydroxymethyl-imidazol-1-yl)-3,3-dimethyl-isochroman-1-one (0.500 g, 1.84 mmol) (Example 6d) in dioxane (10 mL) is added manganese dioxide (2.4 g, 27.6 mmol) and the reaction mixture is heated to 60° C. overnight. Filtration through celite and concentration in vacuo afforded 3-(3,3-dimethyl-1-oxo-isochroman-4-yl)-3H-imidazole-4-carbaldehyde, which is used in the next step without further purification; MS (ESI) m/z 271.1 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08153674B2 |
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| 出典データセット | uspto-grants-2012_04 |
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| ORD ID | ord-54b7373104454b7fbf6fb310ab6c6277 |
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| 出典メモ | uspto-grants-2012_04 |
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