Methylamine → HCID 66707598、化合物

HRID 1690864ノート

反応式

HRID 1690864 の反応式
[CH3:1][NH2:2].C[O:4][C:5](=O)[CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1>CO>[CH:8]1([CH2:7][CH2:6][C:5]([NH:2][CH3:1])=[O:4])[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1

参加物

4

反応物 2

HCID 6329Methylamine2 回HCID 12772855Methyl 3-(cyclohex-3-en-1-yl)propanoate

生成物 1

HCID 66707598HCID 66707598、化合物収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl amine (8 M in EtOH, 75 ml, 600 mmol) was added to a mixture of 3-cyclohex-3-enyl-propionic acid methyl ester (German patent DE 4023848 A1 19920130) (20.0 g, 119 mmol) in 75 mL of methanol. The mixture was stirred at room temperature for one day. Additional Methyl amine (8 M in EtOH, 40 ml, 320 mmol) was added to the mixture and stirring continued for one more day. The mixture was concentrated and the residue was taken up in ethyl acetate, washed with 0.5 M aqueous HCl, dried and stripped of the solvent to give the title compound (19.50 g, 98% yield, uncorrected) as a pale orange solid.

後処理

  1. stirringstirring
  2. concentrationThe mixture was concentrated
  3. washwashed with 0.5 M aqueous HCl
  4. customdried

出典と根拠

ORDレコード
ord-735a23fd81c94ae09058f180f746e49c
出典データセット
uspto-grants-2012_04
特許番号
US08153689B2

反応ノート

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