HCID 59255084、化合物 → HCID 59255317、化合物

HRID 1691173ノート

反応式

HRID 1691173 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][OH:14])=[CH:11][CH:10]=1>[O-2].[O-2].[Mn+4].C(OCC)(=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH:13]=[O:14])=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 59255084HCID 59255084、化合物

生成物 1

HCID 59255317HCID 59255317、化合物収率 82.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

To an ethyl acetate (100 mL) solution of 4-(2-pyridin-2-yl-ethyl)benzyl alcohol (3.16 g, 14.8 mmol) described in Manufacturing Example 93-1-4 was added activated manganese dioxide (45 g, 518 mmol), which was stirred for 4 hours at room temperature. The reaction mixture was filtered through a Celite pad, and washed with ethyl acetate (100 mL). The filtrate was concentrated under a reduced pressure to obtain the title compound (2.57 g, 82%).

後処理

  1. filtrationThe reaction mixture was filtered through a Celite pad
  2. washwashed with ethyl acetate (100 mL)
  3. concentrationThe filtrate was concentrated under a reduced pressure

出典と根拠

ORDレコード
ord-0a7dc349ad0b4456ac5ae35c43eb0adc
出典データセット
uspto-grants-2012_04
特許番号
US08153662B2

反応ノート

読み込み中…