Dicyclopropylmethylamine hydrochloride → HCID 178513036、化合物

反応式

Cl.[CH:2]1([CH:5]([NH2:9])[CH:6]2[CH2:8][CH2:7]2)[CH2:4][CH2:3]1.[C:10]([NH:12][C:13]([NH2:15])=[NH:14])#[N:11]>CCCCCCCCCC.C1(C)C=CC=CC=1>[CH:2]1([CH:5]([NH:9][C:10]([NH:12][C:13]([NH2:15])=[NH:14])=[NH:11])[CH:6]2[CH2:8][CH2:7]2)[CH2:4][CH2:3]1

参加物

実験手順

1.6 g (10.8 mmol) of 1,1-dicyclopropylmethylamine hydrochloride were admixed with 0.91 g (10.8 mmol) of cyanoguanidine in a mixture of 6 ml of decane and 20 ml of toluene. The mixture was heated to a temperature of 140° C. for 5 h, in the course of which toluene distilled off. The flask contents were cooled to room temperature, then acetone was added. The precipitate was decanted off and freed of residual solvent under reduced pressure. 1.7 g of the crude product (purity approx. 80%) were obtained, which were used for the next synthesis stage without further purification.