Water → HCID 59377681、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[O:12][CH3:13].[Br:14]Br.O>CC(O)=O>[Br:14][C:6]1[CH:7]=[C:2]([F:1])[C:3]([O:12][CH3:13])=[CH:4][C:5]=1[CH2:8][C:9]([OH:11])=[O:10]参加物
5
実験手順
To a solution of 4-fluoro-3-methoxyphenylacetic acid (5.0 g, 27.1 mmol) in AcOH (20 ml) was added bromine (1.5 ml, 29.8 mmol). The mixture was stirred at room temperature for three hours. Water was added and the precipitate was isolated by filtration. The white solid was washed with water and dried to give (2-bromo-4-fluoro-5-methoxy-phenyl)-acetic acid (6.21 g, 87%).
後処理
- customthe precipitate was isolated by filtration
- washThe white solid was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-284b0afc0a1f4c049982bd6e7e3cc3dd
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08153808B2
反応ノート
読み込み中…