Sodium Bicarbonate → HCID 59377673、化合物
反応式
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([O:9]C)=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13].C(=O)(O)[O-].[Na+]>ClCCl>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([OH:9])=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13]参加物
4
実験手順
To a solution of (2-bromo-4-fluoro-5-methoxy-phenyl)-acetic acid (6.2 g, 23.5 mmol) in dichloromethane (100 ml) was added 1.0 M borontribromide in dichloromathane (94 ml, 94 mml). The mixture was stirred at room temperature for one hour. Saturated aqueous sodium bicarbonate was added and the mixture was extracted with dichloromathane. The combined organic extract was washed with water and brine, dried over MgSO4, filtered and concentrated to dryness under reduced pressure. Purification by flash chromatography gave (2-bromo-4-fluoro-5-hydroxy-phenyl)-acetic acid (5.2 g, 89%) as a white solid.
後処理
- extractionthe mixture was extracted with dichloromathane
- extractionThe combined organic extract
- washwas washed with water and brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated to dryness under reduced pressure
- customPurification by flash chromatography
出典と根拠
- ORDレコード
- ord-7f52121460694ac1ba0a07c800336bc5
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08153808B2
反応ノート
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