Water → HCID 178508959、化合物

HRID 1691835ノート

反応式

HRID 1691835 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[Br:9]Br.O>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[Br:9]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 1785076342-Amino-6-hydroxypyridine

生成物 1

HCID 178508959HCID 178508959、化合物収率 52.8%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 6-amino-pyridin-2-ol (5 g, 45.4 mmol) in glacial acetic acid (60 mL) was added bromine (2.33 mL, 45.4 mmol) under Ar atmosphere. The mixture was stirred for 20 minutes, then water was added and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (Na2SO4), filtered and concentrated to dryness to obtain crude 6-amino-5-bromo-pyridin-2-ol (4.53 g).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-5bf03174e1a1430cbfb9790ebf829c4b
出典データセット
uspto-grants-2012_04
特許番号
US08153809B2

反応ノート

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