1,1-Dichloroethane → (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

反応式

ClC(Cl)C.[NH2:5][N:6]1[CH2:11][CH2:10][CH:9]([OH:12])[CH2:8][CH2:7]1.C([C@@H]1COC(=O)N1[C:26](=[O:48])[C@H:27]([CH2:31][C:32]1[C:37]([Cl:38])=[CH:36][C:35]([O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)=[CH:34][C:33]=1[Cl:47])[CH2:28][CH:29]=O)C1C=CC=CC=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[CH2:40]([O:39][C:35]1[CH:34]=[C:33]([Cl:47])[C:32]([CH2:31][C@@H:27]2[CH2:28][CH2:29][N:5]([N:6]3[CH2:11][CH2:10][CH:9]([OH:12])[CH2:8][CH2:7]3)[C:26]2=[O:48])=[C:37]([Cl:38])[CH:36]=1)[C:41]1[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=1