関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Benzenemethanol, 2,6-dichloro- | HCID 27156 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | (2,6-Dichlorophenyl)methyl acetate | HCID 261530 | — |
反応手順
Add 500 mL of dichloromethane to 100 g of 2,6-dichlorobenzyl alcohol followed by 117 mL of triethylamine. Cool the solution to 5° C. and add 65 mL of acetic anhydride. After 2.5 hr at room temperature, add another 10 mL of acetic anhydride, 20 mL of triethylamine and 0.5 g of 4-dimethylaminopyridine. Wash the organic layer with 1N HCl followed by saturated aqueous sodium bicarbonate and brine. Dry the organic layer (sodium sulfate) and evaporate to afford 131.5 g of the titled compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08153807B2 |
|---|
| 出典データセット | uspto-grants-2012_04 |
|---|
| ORD ID | ord-459be403d19f41e198d4c744d78b0cf8 |
|---|
| 出典メモ | uspto-grants-2012_04 |
|---|
