Sulfuric Acid → 5-Amino-1-methyl-1H-imidazole-4-carboxamide
反応式
[NH2:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]#[N:9].S(=O)(=O)(O)[OH:11]>>[NH2:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]([NH2:9])=[O:11]参加物
3
実験手順
The cyano group of 5-amino-1-methyl-1H-imidazole-4-carbonitrile 1 is hydrolyzed with sulfuric acid to give 5-amino-1-methyl-1H-imidazole-4-carboxamide 2. Cyclization with urea gives 9-methyl-1H-purine-2,6(3H,9H)-dione 3. Chlorination with phosphorus pentachloride and phosphorusoxychloride gives 2,6-dichloro-9-methyl-9H-purine 4 (CAS Registry 2382-10-7).
出典と根拠
- ORDレコード
- ord-f6e82623cba244ebbb77e2a91b118806
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158625B2
反応ノート
読み込み中…