Bromine → 1-benzenesulfonyl-3-bromo-7-fluoro-1H-indole

HRID 1692883ノート

反応式

HRID 1692883 の反応式
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[F:19])[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)(O)[O-].[Na+].[Br:25]Br>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl.O>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[F:19])[C:12]([Br:25])=[CH:11]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

7

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 116877057-Fluoro-1-(phenylsulfonyl)-1H-indole

生成物 1

HCID 596035291-benzenesulfonyl-3-bromo-7-fluoro-1H-indole収率 95%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 5943Carbon Tetrachloride溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-benzenesulfonyl-7-fluoro-1H-indole (1.00 g, 3.63 mmol) in CCl4 (20 mL) was added a solution of saturated sodium bicarbonate (40 mL) and bromine (0.19 mL, 3.81 mmol) at room temperature. After stirring at room temperature for 16 hours, the reaction was diluted with DCM and water. The organic extract was washed with saturated sodium bicarbonate, 10% aqueous sodium thiosulfate, dried over sodium sulfate, filtered, and concentrated. The product was obtained as an off-white solid (1.22 g, 95%)

後処理

  1. extractionThe organic extract
  2. washwas washed with saturated sodium bicarbonate, 10% aqueous sodium thiosulfate
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-3c5862e76e3f4feb971f97f09d7bf6a5
出典データセット
uspto-grants-2012_04
特許番号
US08158625B2

反応ノート

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