Dimethylformamide → 1-(Cyanomethyl)-3-methylenecyclobutanecarbonitrile
反応式
CS(O[CH2:6][C:7]1([C:12]#[N:13])[CH2:10][C:9](=[CH2:11])[CH2:8]1)(=O)=O.[C-]#N.[K+].[CH3:17][N:18](C)C=O>O>[C:17]([CH2:6][C:7]1([C:12]#[N:13])[CH2:10][C:9](=[CH2:11])[CH2:8]1)#[N:18]参加物
5
反応条件
- 温度
- 65 °C
実験手順
A mixture of (1-cyano-3-methylenecyclobutyl)methyl methanesulfonate (0.41 g, 0.0020 mol) and potassium cyanide (0.66 g, 0.010 mol) in N,N-dimethylformamide (5 mL, 0.06 mol) was heated at 65° C. overnight. After diluting with water, the resulting mixture was extracted with EtOAc. The combined organic layers were washed with water, brine, dried and evaporated to dry. The residue was used directly in next step.
後処理
- extractionthe resulting mixture was extracted with EtOAc
- washThe combined organic layers were washed with water, brine
- customdried
- customevaporated
- customto dry
出典と根拠
- ORDレコード
- ord-b506813bfd04458a87d6207edec7029d
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158616B2
反応ノート
読み込み中…