化工社化工社 化学情報印刷レポート · 研究参考用
Dichloromethane → 2-cyano-N-(1,1-dimethylethyl)-2-(hydroxyimino)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Nitrosyl chloride | HCID 17601 | — |
| 反応物 | N-tert-butyl-2-cyanoacetamide | HCID 1515876 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-cyano-N-(1,1-dimethylethyl)-2-(hydroxyimino)acetamide | HCID 72973983 | — |
反応手順
2-Cyano-N—(1,1-dimethylethyl)acetamide 11 (Bhawal, B. M.; Khanapure, S. P.; Biehl, E. R.; Syn. Commun., 1990, 20, 3235) is allowed to react with nitrosyl chloride in an inert organic solvent such as CH2Cl2 or CHCl3 at moderate temperature (e.g., ambient temperature to −25° C., preferably about 0° C.). The resulting 2-cyano-N-(1,1-dimethylethyl)-2-(hydroxyimino)acetamide 13 is isolated and reduced, for example with sodium dithionite in an aqueous organic solvent, but preferably with aluminum amalgam in water at moderate temperature (e.g., ambient temperature to about 0° C., preferably about 0° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737284B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-943501e6c888465ebf94f27ad6f38802 |
| 出典メモ | uspto-grants-2010_06 |