4-Bromoaniline → HCID 57897867、化合物
反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[Cl:9][C:10]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:11]=1[C:12]([Cl:14])=O.C(N(CC)CC)C>ClCCl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([N:6]=[C:12]([Cl:14])[C:11]2[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:10]=2[Cl:9])=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 4-bromoaniline (40 mg, 0.12 mmol) and 2,4-dichloro benzoyl chloride (69 μL, 0.12 mmol) in dichloromethane is added triethylamine (20 μL, 0.144 mmol). After stirred at room temperature for 30 min, the solvent is removed. The residue is added 0.5 mL of thionyl chloride. The reaction mixture is heated at 80° C. for 1h, concentrated. The product is used in the next step reaction.
後処理
- customthe solvent is removed
- additionThe residue is added 0.5 mL of thionyl chloride
- temperatureThe reaction mixture is heated at 80° C. for 1h
- concentrationconcentrated
- customThe product is used in the next step reaction
出典と根拠
- ORDレコード
- ord-e7105121bd034c838f6bb62745f4efea
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158634B2
反応ノート
読み込み中…