HCID 15554721、化合物 → HCID 57897974、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:10]([N+:11]([O-])=O)=[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:8][N:7]=1)=[O:5])[CH3:2]>CCO.[Ni]>[CH2:1]([O:3][C:4]([C:6]1[C:10]([NH2:11])=[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:8][N:7]=1)=[O:5])[CH3:2]参加物
4
実験手順
To a solution of 4-nitro-5-phenyl-isoxazole-3-carboxylic acid ethyl ester (73.0 mg, 0.278 mmol) in EtOH (2.0 mL) is added Raney Ni and the mixture is stirred under hydrogen (balloon) for overnight. The reaction mixture is then filtered through Celite and evaporated in vacuo to provide crude 4-amino-5-phenyl-isoxazole-3-carboxylic acid ethyl ester (61.7 mg, 95% yield); HPLC-MS calculated for C12H12N2O3 (M+H+) 233.1. Found: 233.1.
後処理
- filtrationThe reaction mixture is then filtered through Celite
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-23b2320ddaaf44dbaccfd5cdcee5ce10
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158634B2
反応ノート
読み込み中…